IGF and proinsulin share homology such that both of their respective receptors, IGFR and the insulin receptor (IR), will bind to the alternate growth factors albeit with reduced affinity (95)
Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis ( 3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Skjevling et al., 2024)
The Amyloid Cascade Hypothesis: Are We Poised for Success or Failure? Journal of Neurochemistry 139: 237252
This lowers the production of glutathione, which requires cysteine rather than cystine, and now there is a vicious circle mechanism that preserves this malfunction and keeps you sick That's the basic biochemical mechanism of CFS everything else flows from this Here's how I believe the fatigue occurs: The cells have little powerplants in them, called mitochondria
doi: 10.1016/j.brainresbull.2018.11.013
