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methylfolate and methylcobalamin), as these do not require metabolism by the MTHFR enzyme

CNS.Drugs 2007;21 Suppl 1:25-30

Each route has different bioavailability, onset, and clinical context

Aja S, Landree LE, Kleman AM, Medghalchi SM, Vadlamudi A, McFadden JM, Aplasca A, Hyun J, Plummer E, Daniels K, Kemm M, Townsend CA, Thupari JN, Kuhajda FP, Moran TH, Ronnett GV: Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight