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Klein, K.W.J

Genetic approaches to the function of insulin-like growth factor-binding proteins during rodent development

Comprehensive scientific literature consistently highlights its direct involvement in wound-healing models, skin and connective tissue research, and systemic antioxidant defense mechanisms

Approach injectable forms cautiously due to absent dosing standardization and regulatory approval

As such, due to the multifaceted nature of chronic wound pathogenesis and susceptibility to abnormalities in ROS balance, interest in the role of ROS in wound healing, as well as the potential applicability of targeting ROS therapeutically, has grown significantly in recent years 14