Acknowledgements The authors are grateful to our participants who generously agreed to participate in this study and wish them full health
In WT animals, consistent with previous reports, we observed significant downregulation of key genes associated with SMCs contractility, including Acta2 , Cacna2d1 , Cnn1 , Myh6 , Myh11 , Adamts6 , and Mylk, indicating loss of SMC contractility phenotype during AAA development
The amino acids L-citrulline and L-arginine both serve as food for NOS to produce NO from (see Figure), with L-citrulline being a precursor to L-arginine.[30],[31] In fact, a 2017 study found that lower serum levels of L-arginine and L-citrulline were more common in men having ED that was vasculogenic in nature.[32] Higher levels of arginine intake have been shown to be associated with higher serum levels of nitrite and nitrate.[33] Supplementation of L-arginine in combination with L-citrulline has been shown to have a greater impact on plasma L-arginine levels than either alone,[34] likely due in part to L-arginines extensive metabolism in the gut.[35] A 2019 systemic review and meta-analysis of randomized controlled trials concludes that supplementation with L-citrulline has a significant effect of lowering both diastolic and systolic blood pressure, with a greater effect in those with a baseline blood pressure of greater than 130/85 mmHg.[36] Studies of L-citrulline supplementation in athletes have shown a positive effect on performance with ongoing supplementation
Benefits: Provides potent antioxidant defense to protect cells from oxidative damage
Recommendations for Ozempic users: Frequency: At minimum, 2-3 resistance training sessions weekly
