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Similarly, curcumin modulates lipid metabolism in THP-1-derived macrophages by upregulating lipid transport genes such as CD36/FAT and FABP-4, leading to lipid accumulation and potentially limiting lipid utilization by tumor cells, ultimately inhibiting tumor growth (135, 136)

Molecular testing Disease-causing mutations in the gene encoding VLCAD, i.e

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doi: 10.1111/JNE.12486 124 OstatnkovDLakatoovSBabkovJHodosyJCelecP

However, its poor water solubility of disulfiram can limit its use in ophthalmic delivery in the form of conventional eye drops, as it struggles to penetrate the cornea and achieve the required drug concentration