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Subjects were 54 healthy adults (41 females/13 males), 28-72 years of age (mean=46.6 years)

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In addition, positive outcomes included lower blood pressure, decreased low-density lipoprotein (LDL)-cholesterol, and enhanced sensitivity to insulin

PARP inhibitors (olaparib, niraparib, rucaparib) have revolutionised maintenance therapy for BRCA-mutated ovarian cancer while exhibiting minimal off-target toxicity toward dormant follicles [135,136,137,138], whose low replicative rate renders them less dependent on poly-ADP-ribose-polymerase activity [139]