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This involves hydrolysis or transpeptidation of GSH at the plasmembrane by -glutamyl transpeptidase (GGT), and intracellular metabolism of -glutamyl amino acid derivatives by glutamyl cyclotransferases (GGC) and 5-oxoprolinase (5-OPase) to produce free glutamate

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As healing progresses, Type I collagen gradually replaces Type III collagen during the remodeling phase