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NO ensures various functions, such as neurotransmission, gene transcription regulation, posttranslational modification of proteins, and m-RNA translation (through binding to iron-responsive elements)

Resp Physiol 128:379391 Wilkinson F, Helman WP, Ross AB (1995) Rate constants for the decay and reactions of the lowest electronically excited singlet-state of molecular oxygen in solution-an expanded and revised compilation

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[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency