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This differential processing of APP is determined by the cellular localization of each secretase, with -secretases predominantly expressed on the cell surface, whereas and -secretases mostly localize in the acidic environment of the endolysosome system (Zhang and Song, 2013)

IHC staining and western blotting confirmed reduced GGCT expression in siGGCT group (Fig

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The diabetic (D Group) showed significant impairment of sperm quality and testicular histology compared with the nondiabetic (ND Group)