Particularly, in some embodiments, hydrophilic active agents are released more quickly, e.g., approximately 50% of drug release after 24 hours, the remainder released over approximately 5 days, whereas hydrophobic agents are released more slowly, e.g., approximately 80% after 8 weeks
Large molecular dipoles come chiefly from bonds to high-electronegative atoms (relative to carbon and hydrogen), especially if they are double or triple bonds
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Despite broad preclinical support, human data are extremely limited