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Acquired metabolic acidosis due to accumulation of 5-oxoproline was first described in adults in 1989 [4]

An important aspect is the modulatory action that microglia exert on astroglial hemichannel/pannexon activity, which seems to be decisive for neuronal function and survival (Montero and Orellana, 2015

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Any chronic medical condition or take multiple medications or supplements

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