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The heme molecule is an essential cofactor for the activities of transport of oxygen and storage proteins, as well as cellular metabolic enzymes, namely those involved in xenobiotic metabolism, mitochondrial respiration and antioxidant responses

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Over a median follow-up time of 21.4 years, 603 participants developed cardiovascular disease, 362 developed diabetes, and 843 participants passed away

Any significant finding by and recommendations of an independent data monitoring committee or equivalent body established for the trial

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