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If your condition is treatable but irreversible (like pernicious anemia), says Green, youll probably need to receive B12 shots or a large oral dose indefinitely

In addition to TfR, the other extensively investigated receptors and transporters for brain targeting are LDL receptor and glucose transporter

Both move fatty acids into mitochondria for energy once they reach the blood, but the injectable route achieves higher and more predictable levels

Glutathione (L--glutamyl-L-cysteinyl-glycine) is the most abundant non-protein thiol in mammalian cells, present in millimolar concentrations throughout the body with particularly high concentrations in the liver, kidneys, and immune tissues