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a,b , Representation of the stationary points calculated with ONIOM(B97X-D/6-311 + G(2d,p):ff14SB,gaff2,TIP3P) G(d):ff14SB,gaff2,TIP3P) for the Pt GSTF8-catalysed deprotonation-protonation reaction: flavan-3-on-4-ol ( 7 ), transition state for deprotonation ( 7-TS ), deprotonation product ( 8-enolate ) and cyanidin ( 8-B4 ) bound to the wild-type enzyme ( a ) and the C13S variant ( b )

To determine kinetic parameters for GR activity of TGR, substrate concentrations varied from 7.5 to 100 M GSSG and from 10 to 100 M NADPH

This therapy is not recommended for individuals who are pregnant, breastfeeding, or have certain medical conditions

Vitamin C injections are generally well tolerated at medically appropriate doses, but high doses can lead to iron overload, kidney stones, and kidney damage

Mutations in Renal Cell Carcinoma