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As creatinine is a breakdown product of creatine phosphate, reduced levels suggest rapid depletion of muscle energy stores during seizures, consistent with increased overall energy demand 34

The most common contributors are: Bone spur (osteophyte) formation as spinal joints develop arthritis, the body lays down extra bone around them

Skatole alleviates osteoarthritis by reprogramming macrophage polarization and protecting chondrocytes

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3 (C)) are in vivo confirmation of in vitro findings on the potential of creatine to remove reactive oxygen species ( Reference Lawler, Barnes and Wu 34 , Reference Sestili, Martinelli and Bravi 35 ) and act as an antioxidant in a dose-dependent response