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Unlike many peptides that are studied primarily for a single biological function, GHK-Cu has been examined across a broad spectrum of cellular processes

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These include improvements in learning and memory, reductions in amyloid plaques and tau phosphorylation, attenuation of cortical and hippocampal neuronal loss, increased neurogenesis, improved synapsis number and plasticity, reduced brain oxidative stress, cerebral anti-inflammatory activity and improved brain insulin receptor localisation and signalling

By inhibiting mitochondrial complex I and suppressing TXNIP, metformin promotes GLUT1 expression and trafficking to intestinal epithelial membranes, increasing glucose excretion and uptake in the distal intestine