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Here, our genetic screening of the previously constructed hairpin RNA-based Arabidopsis library identifies a glutathione (GSH)-deficient mutant that has high accumulation of glutamate (Glu), a previously defined wound signal essential for activating plant defense, but disharmoniously exhibits attenuation of defense signaling events

On the basis of the present data, we suggest that CB-839 as a single agent may not be an option for patients with CLL

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For example, this should include time-of-day chronotherapeutic studies that examine whether exogenous melatonin is most beneficial to be given to patients in relation to endogenous rhythms

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