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Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

Cross-sectional studies have shown that plasma and tissue glutathione concentrations decrease by approximately 10-15% per decade after age 45, and this decline is accelerated in conditions associated with chronic oxidative stress, including type 2 diabetes, cardiovascular disease, neurodegenerative diseases, HIV/AIDS, chronic liver disease, and chronic obstructive pulmonary disease (COPD) [2][3][10][11]

[DOI] [PubMed] [Google Scholar] 48.Tipple T.E., Rogers L.K

Collectively, these findings support the potential use of CCL11 mRNA levels or promoter methylation patterns as biomarkers for VCD in long COVID

It is shaped by neural sensitivity, local inflammation, biomechanics, sleep, and stress