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These in-organ changes in energy metabolism are also reflected in the plasma metabolome after ischemic AKI, which is characterized by the depletion of numerous amino acids and energy substrates 6

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases

doi: 10.1016/j.phytochem.2015.02.017

The authors compare multiple senolytic strategies including FOXO4-DRI, dasatinib plus quercetin, navitoclax, and fisetin, evaluating mechanisms of action, selectivity profiles, and safety considerations for each approach